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Takashi Nishimura Selected Research

Neoplasm Antigens (Tumor Antigens)

1/2015Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): preparation and immunological analysis of vaccine efficacy.
7/2011Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells.
5/2009Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinoma cells.
2/2007Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system.
2/2007Th1 cell adjuvant therapy combined with tumor vaccination: a novel strategy for promoting CTL responses while avoiding the accumulation of Tregs.
1/2007Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma.
3/2006An indispensable role of type-1 IFNs for inducing CTL-mediated complete eradication of established tumor tissue by CpG-liposome co-encapsulated with model tumor antigen.
2/2006An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy.
7/2005Generation of tumor-specific, HLA class I-restricted human Th1 and Tc1 cells by cell engineering with tumor peptide-specific T-cell receptor genes.
12/2004Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity.
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Takashi Nishimura Research Topics

Disease

50Neoplasms (Cancer)
05/2021 - 04/2003
32Heart Failure
04/2022 - 07/2008
29Liver Cirrhosis (Hepatic Cirrhosis)
04/2021 - 06/2016
26Hepatocellular Carcinoma (Hepatoma)
10/2022 - 01/2013
24Liver Diseases (Liver Disease)
07/2021 - 01/2016
12Inflammation (Inflammations)
04/2021 - 07/2006
11Infections
05/2022 - 03/2011
11Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 05/2006
11Chronic Hepatitis C
12/2019 - 01/2012
10Sarcopenia
07/2021 - 08/2017
8Fibrosis (Cirrhosis)
01/2021 - 10/2013
7Carcinoma (Carcinomatosis)
09/2022 - 01/2007
6Varicose Veins (Varicose Vein)
10/2022 - 01/2017
6Disease Progression
01/2022 - 02/2015
6Chronic Hepatitis B
03/2019 - 08/2016
5Chronic Obstructive Pulmonary Disease (COPD)
12/2022 - 10/2011
5Body Weight (Weight, Body)
12/2021 - 07/2008
5Hemorrhage
07/2020 - 06/2011
5Stroke (Strokes)
08/2014 - 09/2002
5Colitis
02/2012 - 12/2007
4Fatigue
06/2022 - 12/2015
4Ascites
05/2022 - 01/2007
4Hypertension (High Blood Pressure)
03/2022 - 07/2008
4Thrombosis (Thrombus)
12/2020 - 03/2011
4Pneumonia (Pneumonitis)
03/2020 - 09/2007
4Adenocarcinoma
02/2020 - 05/2006
4Stomach Neoplasms (Stomach Cancer)
01/2020 - 01/2007
4Pancreatic Neoplasms (Pancreatic Cancer)
01/2020 - 11/2017
4Lung Neoplasms (Lung Cancer)
01/2017 - 02/2008
4Communicable Diseases (Infectious Diseases)
03/2012 - 02/2006
3Cardiac Arrhythmias (Arrythmia)
08/2021 - 01/2021
3Sleep Wake Disorders
08/2020 - 12/2016
3Frailty
08/2020 - 05/2020
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2020 - 05/2006
3Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
12/2015 - 04/2010
3Testicular Neoplasms (Testicular Cancer)
03/2014 - 05/2006
3Lymphoma (Lymphomas)
02/2013 - 01/2004
3Anemia
07/2012 - 02/2009
3Ulcerative Colitis
07/2012 - 01/2007
3Respiratory Hypersensitivity
02/2012 - 10/2004
3Mediastinitis
06/2011 - 07/2010
3Immune System Diseases (Immune Disorders)
11/2010 - 06/2003
3Lewis Lung Carcinoma
05/2009 - 01/2007

Drug/Important Bio-Agent (IBA)

21Proteins (Proteins, Gene)FDA Link
05/2022 - 12/2004
21AntigensIBA
01/2020 - 04/2003
18clonidine-displacing substance (ClDS)IBA
07/2021 - 06/2016
15InterferonsIBA
04/2020 - 04/2003
14Neoplasm Antigens (Tumor Antigens)IBA
01/2015 - 07/2003
13OvalbuminIBA
01/2015 - 07/2003
11Cancer VaccinesIBA
09/2014 - 07/2003
10Bevacizumab (Avastin)FDA Link
10/2022 - 02/2015
10Aspartate Aminotransferases (Aspartate Transaminase)IBA
05/2022 - 07/2014
9AlbuminsIBA
10/2022 - 12/2016
9BilirubinIBA
05/2022 - 01/2011
8atezolizumabIBA
10/2022 - 01/2022
8Serum AlbuminIBA
12/2021 - 10/2013
8CytokinesIBA
01/2021 - 04/2003
8Biomarkers (Surrogate Marker)IBA
08/2018 - 01/2014
8wisteria lectinIBA
03/2017 - 05/2016
8Interleukin-6 (Interleukin 6)IBA
01/2013 - 12/2007
7Hyaluronic Acid (Hyaluronan)IBA
12/2017 - 06/2016
6Antiviral Agents (Antivirals)IBA
05/2022 - 12/2016
6Pharmaceutical PreparationsIBA
04/2022 - 02/2006
6ErbB Receptors (EGF Receptor)IBA
01/2022 - 08/2010
6Alanine Transaminase (SGPT)IBA
04/2021 - 03/2016
6ZincIBA
05/2020 - 03/2019
6Monoclonal AntibodiesIBA
12/2019 - 04/2003
6Peptides (Polypeptides)IBA
01/2015 - 01/2004
6Interleukin-12 (IL 12)IBA
12/2011 - 04/2003
5Ribavirin (Virazole)FDA LinkGeneric
12/2016 - 07/2011
5Interleukin-4 (Interleukin 4)IBA
10/2009 - 01/2004
5T-Cell Antigen Receptors (T-Cell Receptor)IBA
09/2006 - 10/2003
4SteroidsIBA
01/2022 - 08/2005
4Pemetrexed (MTA)FDA Link
01/2022 - 01/2013
4Glucose (Dextrose)FDA LinkGeneric
05/2021 - 02/2002
4Sorafenib (BAY 43-9006)FDA Link
08/2017 - 01/2014
4EpitopesIBA
01/2015 - 01/2012
4Liposomes (Liposome)IBA
05/2009 - 09/2004
3Oxygen (Dioxygen)IBA
12/2022 - 09/2002
3Insulin (Novolin)FDA Link
02/2022 - 02/2002
3Docetaxel (Taxotere)FDA Link
01/2022 - 08/2015
3Carrier Proteins (Binding Protein)IBA
12/2019 - 12/2017
3DNA (Deoxyribonucleic Acid)IBA
08/2018 - 04/2010
316S Ribosomal RNAIBA
08/2018 - 12/2009
3PlatinumIBA
07/2017 - 08/2015
3Paclitaxel (Taxol)FDA LinkGeneric
07/2017 - 01/2007
3SodiumIBA
05/2017 - 04/2011
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2016 - 04/2009
3Messenger RNA (mRNA)IBA
03/2014 - 11/2008
3Therapeutic UsesIBA
04/2010 - 08/2003

Therapy/Procedure

71Therapeutics
12/2022 - 07/2003
35Heart-Assist Devices
04/2022 - 07/2008
14Drug Therapy (Chemotherapy)
01/2022 - 01/2007
12Immunotherapy
10/2022 - 07/2003
5Transplantation
09/2014 - 02/2008
5Cell- and Tissue-Based Therapy (Cell Therapy)
01/2012 - 04/2003
4Extracorporeal Membrane Oxygenation
09/2022 - 05/2011
4Negative-Pressure Wound Therapy
01/2014 - 07/2010
3Cannula
12/2022 - 03/2011
3Radiotherapy
04/2010 - 01/2007